Retatrutide
Retatrutide – 12mg / 24mg Vial
Retatrutide is a compounded injectable peptide designed for advanced weight loss and metabolic support. It functions as a triple agonist of GLP-1, GIP, and glucagon receptors, offering enhanced fat-burning and appetite control effects.
- Boosts metabolism and promotes fat breakdown
- Reduces appetite and prolongs feelings of fullness
- Improves insulin sensitivity and supports blood sugar balance
Retatrutide
Benefits
- Triple receptor agonist with additional glucagon receptor activity
- Supports significant weight loss (up to 25%)
- Gentle on the stomach, reducing GI discomfort
- Increases energy and reduces brain fog
- Helps regulate blood sugar and appetite
- May improve metabolic and cardiovascular health
Protocols
Protocols:
- Start with the lowest dose to minimize side effects
- Increase gradually following the titration schedule
- Inject on the same day each week for consistency
Injection Type
Subcutaneous (SubQ) injection
Recommended Dose
- Start at 2 mg once weekly (week 1–4)
- Gradually increase to 12 mg once weekly as tolerated
- Dose in units depends on your vial concentration — calculate using the mg/unit formula
- Administer at the same time and day each week
Frequency
- Once weekly
How to Increase the Dose (Titration Schedule)
- Weeks 1–4: 2 mg once weekly
- Weeks 5–8: Increase to 4 mg once weekly if well-tolerated
- Weeks 9–12: Increase to 6 mg once weekly
- Weeks 13–16: Increase to 8 mg once weekly
- Weeks 17–20: Increase to 10 mg once weekly
- Weeks 21+ (Maintenance): Up to 12 mg once weekly if needed for optimal results
- If nausea, bloating, or discomfort occurs, maintain current dose longer before increasing
Dosing
(1 mL / 100-unit insulin syringe)
GLP-1 R (12mg/1.2ml vial)
Dose (mg) | Units | Notes |
2 mg | 20 units | Starting dose (Weeks 1–4) |
4 mg | 40 units | Step 2 (Weeks 5–8) |
6 mg | 60 units | Step 3 (Weeks 9–12) |
8 mg | 80 units | Step 4 (Weeks 13–16) |
10 mg | 100 units | Step 5 (Weeks 17–20) |
12 mg | 120 units | Maximum recommended dose |
(1 mL / 100-unit insulin syringe)
GLP-1 R (24mg/2.4ml vial):
Dose (mg) | Units | Notes |
2 mg | 20 units | Starting dose (Weeks 1–4) |
4 mg | 40 units | Step 2 (Weeks 5–8) |
6 mg | 60 units | Step 3 (Weeks 9–12) |
8 mg | 80 units | Step 4 (Weeks 13–16) |
10 mg | 100 units | Step 5 (Weeks 17–20) |
12 mg | 120 units | Maximum recommended dose |
Frequently Asked Questions
What is Retatrutide and how does it work?
Retatrutide is a triple agonist peptide that targets GLP-1, GIP, and glucagon receptors. It helps regulate appetite, improve metabolism, and burn fat more effectively than single-pathway medications.
What are the main benefits of using Retatrutide?
Benefits include appetite control, fat loss (especially visceral fat), improved insulin sensitivity, better blood sugar levels, and long-lasting satiety.
How is Retatrutide administered?
It is given as a subcutaneous injection once per week, typically in the abdomen, thigh, or upper arm.
Who is a good candidate for Retatrutide?
CAdults looking to lose weight, manage obesity, or improve metabolic health. It may also benefit those with prediabetes or type 2 diabetes, pending medical evaluation.
Are there any side effects?
Common side effects may include mild nausea, bloating, or fatigue, especially in the first few doses. Most symptoms lessen as your body adjusts. Always consult your provider for guidance.
Can Retatrutide be combined with other treatments?
Yes, it can be stacked with other peptides like AOD-9604 or NAD+ for enhanced results, especially in fat loss or anti-aging protocols—based on professional recommendation.
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