Semaglutide
Semaglutide – 5 mg / 10 mg / 20 mg Vial
Semaglutide is a compounded injectable medication used to support medical weight loss. It mimics the GLP-1 hormone to help regulate appetite, glucose levels, and digestion.
- Slows gastric emptying to reduce hunger
- Increases insulin secretion and lowers blood sugar
- Promotes a feeling of fullness with less food intake Commonly used for chronic weight management in patients with obesity or overweight (BMI ≥27 with comorbidities).
Semaglutide
Benefits
- GLP-1 receptor agonist that enhances insulin secretion
- Lowers blood sugar levels and improves glycemic control
- Supports significant weight loss (average ~15%)
- Helps reduce appetite and cravings
- May improve cardiovascular health markers
- Once-weekly injection for convenience
Protocols
Protocols:
- Start with the lowest dose to minimize side effects
- Increase gradually following the titration schedule
- Inject on the same day each week for consistency
Injection Type
Subcutaneous (SubQ) injection
Recommended Dose
- Start at 0.25 mg once weekly (week 1–4)
- Gradually increase to 2.5 mg once weekly as tolerated
- Dose in units depends on your vial concentration — calculate using the mg/unit formula
- Administer at the same time and day each week
Frequency
- Once weekly
How to Increase the Dose (Titration Schedule)
- Weeks 1–4: 0.25 mg once weekly
- Weeks 5–8: Increase to 0.5 mg once weekly if well-tolerated
- Weeks 9–12: Increase to 1.0 mg once weekly
- Weeks 13–16: Increase to 1.5 mg once weekly
- Weeks 17+ (Maintenance): Up to 2.5 mg once weekly if needed for optimal results
- If nausea or discomfort occurs, hold the current dose longer before increasing
Dosing
Semaglutide 5MG/2ML Vial
Dose (mg) | Insulin Units |
0.25 mg | 10 units |
0.5 mg | 20 units |
0.625 mg | 25 units |
0.75 mg | 30 units |
1.0 mg | 40 units |
1.25 mg | 50 units |
Semaglutide 10MG/2ML Vial
Dose (mg) | Insulin Units |
0.25 mg | 5 units |
0.5 mg | 10 units |
0.625 mg | 12.5 units |
0.75 mg | 15 units |
1.0 mg | 20 units |
1.25 mg | 25 units |
1.5 mg | 30 units |
1.75 mg | 35 units |
2.0 mg | 40 units |
Semaglutide 20MG/2ML Vial
Dose (mg) | Insulin Units |
0.25 mg | 2.5 units |
0.5 mg | 5 units |
0.625 mg | 6.25 units |
0.75 mg | 7.5 units |
1.0 mg | 10 units |
1.25 mg | 12.5 units |
1.5 mg | 15 units |
1.75 mg | 17.5 units |
2.0 mg | 20 units |
Frequently Asked Questions
What is Semaglutide and how does it work?
Semaglutide is a medication used to lower blood sugar in people with type 2 diabetes and to help with weight loss.
It works by mimicking a natural hormone (GLP-1) that helps regulate appetite, insulin, and digestion.
How is Semaglutide vial injection used?
The medication is usually injected under the skin (subcutaneously) once a week.
You’ll mix the vial with sterile water (reconstitution) before use. Always follow your provider’s instructions carefully.
Where do I inject Semaglutide?
Common injection sites include:
Stomach (abdomen)
Thigh
Upper arm
Rotate injection sites weekly to avoid irritation.
How should I store the vial?
Before mixing: Store at room temperature (68°F–77°F / 20°C–25°C), away from light.
After mixing: Refrigerate and use within the time recommended by your provider (usually 28 days).
Are there any side effects?
Common side effects include:
Nausea
Vomiting
Diarrhea
Constipation
These often lessen over time. Contact your doctor if symptoms are severe or persistent.
Can I use Semaglutide for weight loss even if I’m not diabetic?
Yes, with a doctor’s prescription.
Many providers prescribe Semaglutide “off-label” for weight management in people with obesity or overweight.
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